Rapid alignment-free phylogenetic identification of metagenomic sequences.
Identifieur interne : 000011 ( France/Analysis ); précédent : 000010; suivant : 000012Rapid alignment-free phylogenetic identification of metagenomic sequences.
Auteurs : Benjamin Linard [France] ; Krister Swenson [France] ; Fabio Pardi [France]Source :
- Bioinformatics (Oxford, England) [ 1367-4811 ] ; 2019.
Abstract
Taxonomic classification is at the core of environmental DNA analysis. When a phylogenetic tree can be built as a prior hypothesis to such classification, phylogenetic placement (PP) provides the most informative type of classification because each query sequence is assigned to its putative origin in the tree. This is useful whenever precision is sought (e.g. in diagnostics). However, likelihood-based PP algorithms struggle to scale with the ever-increasing throughput of DNA sequencing.
DOI: 10.1093/bioinformatics/btz068
PubMed: 30698645
Affiliations:
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pubmed:30698645Le document en format XML
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<front><div type="abstract" xml:lang="en">Taxonomic classification is at the core of environmental DNA analysis. When a phylogenetic tree can be built as a prior hypothesis to such classification, phylogenetic placement (PP) provides the most informative type of classification because each query sequence is assigned to its putative origin in the tree. This is useful whenever precision is sought (e.g. in diagnostics). However, likelihood-based PP algorithms struggle to scale with the ever-increasing throughput of DNA sequencing.</div>
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